اثر مصرف خوراکی لسیتین و ویتامین A بر یادگیری متعاقب تخریب دو طرفه نواحی خلفی جانبی CA1 در موش صحرایی

Background and Objective: There are a number of studies, which focused on the improvement of reorganization disease such as Alzheimer. These investigations emphasis on the role of hippocampus on spatial learning of rats. In this study, we investigated the effects of oral administration of lecithin (Lc) and Vitamin A (VitA) on learning and memory of the adult male rats in absence of posterolateral area of CA1 (PLCA1). Materials and Methods: In this experimental study 56 adult male NMRI rats (275±25g) were used. After lesion in PLCA1 all animals were trained for passive avoidance memory (PAM) by shuttle box. The animals were divided into 8 groups as follow: Control [(non administration), sham (Oral distilled water (dw), sham operated (only electrode insertion), Lesion (le) (PLCA1 disrupted)], four test groups (le +dw), (le + Lc 120 mg/kg), (le + VitA 80000Iu/kg) and (le+ Lc + VitA). All administrations (10 mg/kg B.W) were done orally for 7days, one hour before each experiment. Results: The result showed significant difference between Le and sham operated groups regarding first and second phase of remembering (p<0.05). Co-administration of Lc and VitA can repair PAM of injured rats in comparison with le+dw group significantly (p<0.05), and the VitA had no significant effect on the IAM of injured rats. Administration of VitA significantly reduced memory of the rat-PLCA1 (p<0.05). Conclusion: Bilaterally local lesion of CA1 is able to reduce passive avoidance memory. It seems that co- administration of Le and VitA, can improve PAM of CA1–lesion rats. Key words: Hippocampus, Lecithin, Vitamin A, Inactive Avoidance Memory